Recent Changes - Search:

MLFL Home

University of Massachusetts

MLFL Wiki

A Nonparametric Bayesian Model For Single-cell Variant Calling

Abstract:

Advances in DNA sequencing technology have enabled surprising discoveries in basic science and novel diagnostics in personalized medicine. Recently, the ability to read the DNA sequence of a single cell has presented new statistical and computational challenges. We address the problem of calling single-nucleotide mutations in single-cell sequencing data. We present some results evaluating existing mutation calling algorithms on data generated from a single-cell sequence data simulator. We describe a nonparametric Bayesian generative model for combining single-cell and bulk DNA sequencing data, and we show preliminary results from this model.

Bio:

Patrick Flaherty is a Professor in the Department of Mathematics & Statistics at UMass Amherst. He received his PhD in Electrical Engineering and Computer Science from the University of California, Berkeley and he was a postdoctoral scholar at Stanford University in the Department of Biochemistry. His research focuses on scalable, statistical methods for analyzing large genomic data sets.

Edit - History - Print - Recent Changes - Search
Page last modified on September 11, 2017, at 07:07 PM